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Early Intra-Articular Complement Activation in Ankle Fractures
المؤلفون المشاركون
Guo, Renfeng
Langenmair, Elia Raoul
Niemeyer, Philipp
Habel, Maria
Salzmann, Gian M.
Riedemann, Niels
Schneider, Conny
Schmal, Hagen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cytokine regulation possibly influences long term outcome following ankle fractures, but little is known about synovial fracture biochemistry.
Eight patients with an ankle dislocation fracture were included in a prospective case series and matched with patients suffering from grade 2 osteochondritis dissecans (OCD) of the ankle.
All fractures needed external fixation during which joint effusions were collected.
Fluid analysis was done by ELISA measuring aggrecan, bFGF, IL-1β, IGF-1, and the complement components C3a, C5a, and C5b-9.
The time periods between occurrence of fracture and collection of effusion were only significantly associated with synovial aggrecan and C5b-9 levels (P<0.001).
Furthermore, synovial expressions of both proteins correlated with each other (P<0.001).
Although IL-1β expression was relatively low, intra-articular levels correlated with C5a (P<0.01) and serological C-reactive protein concentrations 2 days after surgery (P<0.05).
Joint effusions were initially dominated by neutrophils, but the portion of monocytes constantly increased reaching 50% at day 6 after fracture (P<0.02).
Whereas aggrecan and IL-1β concentrations were not different in fracture and OCD patients, bFGF, IGF-1, and all complement components were significantly higher concentrated in ankle joints with fractures (P<0.01).
Complement activation and inflammatory cell infiltration characterize the joint biology following acute ankle fractures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schmal, Hagen& Salzmann, Gian M.& Niemeyer, Philipp& Langenmair, Elia Raoul& Guo, Renfeng& Schneider, Conny…[et al.]. 2014. Early Intra-Articular Complement Activation in Ankle Fractures. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-471319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schmal, Hagen…[et al.]. Early Intra-Articular Complement Activation in Ankle Fractures. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-471319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schmal, Hagen& Salzmann, Gian M.& Niemeyer, Philipp& Langenmair, Elia Raoul& Guo, Renfeng& Schneider, Conny…[et al.]. Early Intra-Articular Complement Activation in Ankle Fractures. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-471319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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