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Early Intra-Articular Complement Activation in Ankle Fractures
Joint Authors
Guo, Renfeng
Langenmair, Elia Raoul
Niemeyer, Philipp
Habel, Maria
Salzmann, Gian M.
Riedemann, Niels
Schneider, Conny
Schmal, Hagen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cytokine regulation possibly influences long term outcome following ankle fractures, but little is known about synovial fracture biochemistry.
Eight patients with an ankle dislocation fracture were included in a prospective case series and matched with patients suffering from grade 2 osteochondritis dissecans (OCD) of the ankle.
All fractures needed external fixation during which joint effusions were collected.
Fluid analysis was done by ELISA measuring aggrecan, bFGF, IL-1β, IGF-1, and the complement components C3a, C5a, and C5b-9.
The time periods between occurrence of fracture and collection of effusion were only significantly associated with synovial aggrecan and C5b-9 levels (P<0.001).
Furthermore, synovial expressions of both proteins correlated with each other (P<0.001).
Although IL-1β expression was relatively low, intra-articular levels correlated with C5a (P<0.01) and serological C-reactive protein concentrations 2 days after surgery (P<0.05).
Joint effusions were initially dominated by neutrophils, but the portion of monocytes constantly increased reaching 50% at day 6 after fracture (P<0.02).
Whereas aggrecan and IL-1β concentrations were not different in fracture and OCD patients, bFGF, IGF-1, and all complement components were significantly higher concentrated in ankle joints with fractures (P<0.01).
Complement activation and inflammatory cell infiltration characterize the joint biology following acute ankle fractures.
American Psychological Association (APA)
Schmal, Hagen& Salzmann, Gian M.& Niemeyer, Philipp& Langenmair, Elia Raoul& Guo, Renfeng& Schneider, Conny…[et al.]. 2014. Early Intra-Articular Complement Activation in Ankle Fractures. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-471319
Modern Language Association (MLA)
Schmal, Hagen…[et al.]. Early Intra-Articular Complement Activation in Ankle Fractures. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-471319
American Medical Association (AMA)
Schmal, Hagen& Salzmann, Gian M.& Niemeyer, Philipp& Langenmair, Elia Raoul& Guo, Renfeng& Schneider, Conny…[et al.]. Early Intra-Articular Complement Activation in Ankle Fractures. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-471319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471319