Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target
المؤلفون المشاركون
Barbieri, Federica
Florio, Tullio
Bajetto, Adriana
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-12-14
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Ovarian cancer is the most common type of gynecologic malignancy.
Despite advances in surgery and chemotherapy, the survival rate is still low since most ovarian cancers relapse and become drug-resistant.
Chemokines are small chemoattractant peptides mainly involved in the immune responses.
More recently, chemokines were also demonstrated to regulate extra-immunological functions.
It was shown that the chemokine network plays crucial functions in the tumorigenesis in several tissues.
In particular the imbalanced or aberrant expression of CXCL12 and its receptor CXCR4 strongly affects cancer cell proliferation, recruitment of immunosuppressive cells, neovascularization, and metastasization.
In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies.
This chemokine ligand/receptor pair was also proposed to represent an innovative therapeutic target for the treatment of ovarian cancer.
Thus, a thorough understanding of ovarian cancer biology, and how chemokines may control these different biological activities might lead to the development of more effective therapies.
This paper will focus on the current biology of CXCL12/CXCR4 axis in the context of understanding their potential role in ovarian cancer development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barbieri, Federica& Bajetto, Adriana& Florio, Tullio. 2009. Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target. Journal of Oncology،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-471328
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barbieri, Federica…[et al.]. Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target. Journal of Oncology No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-471328
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barbieri, Federica& Bajetto, Adriana& Florio, Tullio. Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-471328
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471328
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر