Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target
Joint Authors
Barbieri, Federica
Florio, Tullio
Bajetto, Adriana
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Ovarian cancer is the most common type of gynecologic malignancy.
Despite advances in surgery and chemotherapy, the survival rate is still low since most ovarian cancers relapse and become drug-resistant.
Chemokines are small chemoattractant peptides mainly involved in the immune responses.
More recently, chemokines were also demonstrated to regulate extra-immunological functions.
It was shown that the chemokine network plays crucial functions in the tumorigenesis in several tissues.
In particular the imbalanced or aberrant expression of CXCL12 and its receptor CXCR4 strongly affects cancer cell proliferation, recruitment of immunosuppressive cells, neovascularization, and metastasization.
In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies.
This chemokine ligand/receptor pair was also proposed to represent an innovative therapeutic target for the treatment of ovarian cancer.
Thus, a thorough understanding of ovarian cancer biology, and how chemokines may control these different biological activities might lead to the development of more effective therapies.
This paper will focus on the current biology of CXCL12/CXCR4 axis in the context of understanding their potential role in ovarian cancer development.
American Psychological Association (APA)
Barbieri, Federica& Bajetto, Adriana& Florio, Tullio. 2009. Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target. Journal of Oncology،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-471328
Modern Language Association (MLA)
Barbieri, Federica…[et al.]. Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target. Journal of Oncology No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-471328
American Medical Association (AMA)
Barbieri, Federica& Bajetto, Adriana& Florio, Tullio. Role of Chemokine Network in the Development and Progression of Ovarian Cancer : A Potential Novel Pharmacological Target. Journal of Oncology. 2009. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-471328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471328