Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root
المؤلفون المشاركون
Chopra, Madhu
Srivastava, Rakhi
Dwarakanath, Bilikere S.
Saluja, Daman
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In Indian traditional medicine, Boerhaavia diffusa (punarnava) roots have been widely used for the treatment of dyspepsia, jaundice, enlargement of spleen, abdominal pain and as an anti-stress agent.
Pharmacological evaluation of the crude ethanolic extract of B.
diffusa roots has been shown to possess antiproliferative and immunomodulatory properties.
The extract of B.
diffusa was studied for anti-proliferative effects on the growth of HeLa cells and for its effect on cell cycle.
Bio-assays of extracts from B.
diffusa root showed that a methanol : chloroform fraction (BDF 5) had an antiproliferative effect on HeLa cells.
After 48 h of exposure, this fraction at a concentration of 200 μg mL−1 significantly reduced cell proliferation with visible morphological changes in HeLa cells.
Cell cycle analysis suggests that antiproliferative effect of BDF 5 could be due to inhibition of DNA synthesis in S-phase of cell cycle in HeLa cells, whereas no significant change in cell cycle was detected in control cells.
The fraction BDF 5 caused cell death via apoptosis as evident from DNA fragmentation and caspase-9 activation.
Thus the extract has potential to be evaluated in detail to assess the molecular mechanism-mediated anticancer activities of this plant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Srivastava, Rakhi& Saluja, Daman& Dwarakanath, Bilikere S.& Chopra, Madhu. 2011. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-471339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Srivastava, Rakhi…[et al.]. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-471339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Srivastava, Rakhi& Saluja, Daman& Dwarakanath, Bilikere S.& Chopra, Madhu. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-471339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر