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Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root
Joint Authors
Chopra, Madhu
Srivastava, Rakhi
Dwarakanath, Bilikere S.
Saluja, Daman
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In Indian traditional medicine, Boerhaavia diffusa (punarnava) roots have been widely used for the treatment of dyspepsia, jaundice, enlargement of spleen, abdominal pain and as an anti-stress agent.
Pharmacological evaluation of the crude ethanolic extract of B.
diffusa roots has been shown to possess antiproliferative and immunomodulatory properties.
The extract of B.
diffusa was studied for anti-proliferative effects on the growth of HeLa cells and for its effect on cell cycle.
Bio-assays of extracts from B.
diffusa root showed that a methanol : chloroform fraction (BDF 5) had an antiproliferative effect on HeLa cells.
After 48 h of exposure, this fraction at a concentration of 200 μg mL−1 significantly reduced cell proliferation with visible morphological changes in HeLa cells.
Cell cycle analysis suggests that antiproliferative effect of BDF 5 could be due to inhibition of DNA synthesis in S-phase of cell cycle in HeLa cells, whereas no significant change in cell cycle was detected in control cells.
The fraction BDF 5 caused cell death via apoptosis as evident from DNA fragmentation and caspase-9 activation.
Thus the extract has potential to be evaluated in detail to assess the molecular mechanism-mediated anticancer activities of this plant.
American Psychological Association (APA)
Srivastava, Rakhi& Saluja, Daman& Dwarakanath, Bilikere S.& Chopra, Madhu. 2011. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-471339
Modern Language Association (MLA)
Srivastava, Rakhi…[et al.]. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-471339
American Medical Association (AMA)
Srivastava, Rakhi& Saluja, Daman& Dwarakanath, Bilikere S.& Chopra, Madhu. Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-471339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471339