Cytogenetics Findings in a Histiocytic Sarcoma Case

الملخص EN

Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes.

Its diagnosis was not clear until its immunohistochemistry profile was correctly established.

Not much is known about its genetic properties.

We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity.

Its immunohistochemical profile was CD68+, CD4+, CD45+ with negativity of other dendritic cells, and other lineage markers.

Cytogenetic study showed 4 related clones: one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35).

To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.