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Cytogenetics Findings in a Histiocytic Sarcoma Case
Joint Authors
Villalon, C.
Abalo, L.
Ferro, M. T.
Lopez-Jimenez, J.
Garcia-Gutierrez, J. V.
Villarrubia, J.
Lozano, S.
Talavera, M.
Alonso-Dominguez, J. M.
Calbacho, M.
Tenorio, M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Histiocytic sarcoma (HS) is a neoplasm derived from histiocytes.
Its diagnosis was not clear until its immunohistochemistry profile was correctly established.
Not much is known about its genetic properties.
We report a case of a 48-year-old male patient whose bone marrow was almost completely occupied by monomorphic medium size neoplastic cellularity.
Its immunohistochemical profile was CD68+, CD4+, CD45+ with negativity of other dendritic cells, and other lineage markers.
Cytogenetic study showed 4 related clones: one with trisomy 8 and extra material on the short arms of chromosome 4; a second line with tetrasomy of chromosome 8, add(4)(p16); the third clone had the same alterations as the previous and deletion of chromosome 3 at q11; the fourth line had tetrasomy 8 and translocation t(3;5)(q25;q35).
To our knowledge this is the first HS case showing chromosome 8 trisomy and tetrasomy and the other described alterations.
American Psychological Association (APA)
Alonso-Dominguez, J. M.& Calbacho, M.& Talavera, M.& Villalon, C.& Abalo, L.& Garcia-Gutierrez, J. V.…[et al.]. 2012. Cytogenetics Findings in a Histiocytic Sarcoma Case. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-471456
Modern Language Association (MLA)
Alonso-Dominguez, J. M.…[et al.]. Cytogenetics Findings in a Histiocytic Sarcoma Case. Case Reports in Hematology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-471456
American Medical Association (AMA)
Alonso-Dominguez, J. M.& Calbacho, M.& Talavera, M.& Villalon, C.& Abalo, L.& Garcia-Gutierrez, J. V.…[et al.]. Cytogenetics Findings in a Histiocytic Sarcoma Case. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-471456
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471456