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Recombinant Expression and Characterization of Human and Murine ACE2 : Species-Specific Activation of the Alternative Renin-Angiotensin-System
المؤلفون المشاركون
Domenig, Oliver
Wagner, Bettina
Schwager, Cornelia
Peball, Bernhard
Schuster, Manfred
Janzek, Evelyne
Stranner, Stefan
Loibner, Hans
Poglitsch, Marko
Jungwirth, Helmut
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase of the renin-angiotensin-system (RAS) which is known to cleave several substrates among vasoactive peptides.
Its preferred substrate is Angiotensin II, which is tightly involved in the regulation of important physiological functions including fluid homeostasis and blood pressure.
Ang 1–7, the main enzymatic product of ACE2, became increasingly important in the literature in recent years, as it was reported to counteract hypertensive and fibrotic actions of Angiotensin II via the MAS receptor.
The functional connection of ACE2, Ang 1–7, and the MAS receptor is also referred to as the alternative axis of the RAS.
In the present paper, we describe the recombinant expression and purification of human and murine ACE2 (rhACE2 and rmACE2).
Furthermore, we determined the conversion rates of rhACE2 and rmACE2 for different natural peptide substrates in plasma samples and discovered species-specific differences in substrate specificities, probably leading to functional differences in the alternative axis of the RAS.
In particular, conversion rates of Ang 1–10 to Ang 1–9 were found to be substantially different when applying rhACE2 or rmACE2 in vitro.
In contrast to rhACE2, rm ACE2 is substantially less potent in transformation of Ang 1–10 to Ang 1–9.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Poglitsch, Marko& Domenig, Oliver& Schwager, Cornelia& Stranner, Stefan& Peball, Bernhard& Janzek, Evelyne…[et al.]. 2012. Recombinant Expression and Characterization of Human and Murine ACE2 : Species-Specific Activation of the Alternative Renin-Angiotensin-System. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471521
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Poglitsch, Marko…[et al.]. Recombinant Expression and Characterization of Human and Murine ACE2 : Species-Specific Activation of the Alternative Renin-Angiotensin-System. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-471521
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Poglitsch, Marko& Domenig, Oliver& Schwager, Cornelia& Stranner, Stefan& Peball, Bernhard& Janzek, Evelyne…[et al.]. Recombinant Expression and Characterization of Human and Murine ACE2 : Species-Specific Activation of the Alternative Renin-Angiotensin-System. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-471521
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471521
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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