Control of Differentiation of Human Mesenchymal Stem Cells by Altering the Geometry of Nanofibers
المؤلفون المشاركون
Shimizu, Harue
Fujita, Satoshi
Suye, Shin-ichiro
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الهندسية و تكنولوجيا المعلومات
الكيمياء
الملخص EN
Effective differentiation of mesenchymal stem cells (MSCs) is required for clinical applications.
To control MSC differentiation, induction media containing different types of soluble factors have been used to date; however, it remains challenging to obtain a uniformly differentiated population of an appropriate quality for clinical application by this approach.
We attempted to develop nanofiber scaffolds for effective MSC differentiation by mimicking anisotropy of the extracellular matrix structure, to assess whether differentiation of these cells can be controlled by using geometrically different scaffolds.
We evaluated MSC differentiation on aligned and random nanofibers, fabricated by electrospinning.
We found that induction of MSCs into adipocytes was markedly more inhibited on random nanofibers than on aligned nanofibers.
In addition, adipoinduction on aligned nanofibers was also inhibited in the presence of mixed adipoinduction and osteoinduction medium, although osteoinduction was not affected by a change in scaffold geometry.
Thus, we have achieved localized control over the direction of differentiation through changes in the alignment of the scaffold even in the presence of a mixed medium.
These findings indicate that precise control of MSC differentiation can be attained by using scaffolds with different geometry, rather than by the conventional use of soluble factors in the medium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fujita, Satoshi& Shimizu, Harue& Suye, Shin-ichiro. 2012. Control of Differentiation of Human Mesenchymal Stem Cells by Altering the Geometry of Nanofibers. Journal of Nanotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471629
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fujita, Satoshi…[et al.]. Control of Differentiation of Human Mesenchymal Stem Cells by Altering the Geometry of Nanofibers. Journal of Nanotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-471629
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fujita, Satoshi& Shimizu, Harue& Suye, Shin-ichiro. Control of Differentiation of Human Mesenchymal Stem Cells by Altering the Geometry of Nanofibers. Journal of Nanotechnology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-471629
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471629
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر