A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats

المؤلفون المشاركون

Zhao, Liang-Cai
Wang, He-Yao
Zhang, Xiao-Dong
Gao, Hong-Chang
Lin, Dong-Hai
Liao, Shi-Xian

المصدر

Journal of Biomedicine and Biotechnology

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-10-13

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

To further investigate pathogenesis and pathogenic process of type 2 diabetes mellitus (T2DM), we compared the urinary metabolic profiling of Zucker obese and Goto-kakizaki (GK) rats by NMR-based metabonomics.

Principal component analysis (PCA) on urine samples of both models rats indicates markedly elevated levels of creatine/creatinine, dimethylamine, and acetoacetate, with concomitantly declined levels of citrate, 2-ketoglurarate, lactate, hippurate, and succinate compared with control rats, respectively.

Simultaneously, compared with Zucker obese rats, the GK rats show decreased levels of trimethylamine, acetate, and choline, as well as increased levels of creatine/creatinine, acetoacetate, alanine, citrate, 2-ketoglutarate, succinate, lactate, and hippurate.

This study demonstrates metabolic similarities between the two stages of T2DM, including reduced tricarboxylic acid (TCA) cycle and increased ketone bodies production.

In addition, compared with Zucker obese rats, the GK rats have enhanced concentration of energy metabolites, which indicates energy metabolic changes produced in hyperglycemia stage more than in insulin resistance stage.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhao, Liang-Cai& Zhang, Xiao-Dong& Liao, Shi-Xian& Gao, Hong-Chang& Wang, He-Yao& Lin, Dong-Hai. 2010. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-471792

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhao, Liang-Cai…[et al.]. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-471792

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhao, Liang-Cai& Zhang, Xiao-Dong& Liao, Shi-Xian& Gao, Hong-Chang& Wang, He-Yao& Lin, Dong-Hai. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-471792

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-471792