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A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats
Joint Authors
Zhao, Liang-Cai
Wang, He-Yao
Zhang, Xiao-Dong
Gao, Hong-Chang
Lin, Dong-Hai
Liao, Shi-Xian
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To further investigate pathogenesis and pathogenic process of type 2 diabetes mellitus (T2DM), we compared the urinary metabolic profiling of Zucker obese and Goto-kakizaki (GK) rats by NMR-based metabonomics.
Principal component analysis (PCA) on urine samples of both models rats indicates markedly elevated levels of creatine/creatinine, dimethylamine, and acetoacetate, with concomitantly declined levels of citrate, 2-ketoglurarate, lactate, hippurate, and succinate compared with control rats, respectively.
Simultaneously, compared with Zucker obese rats, the GK rats show decreased levels of trimethylamine, acetate, and choline, as well as increased levels of creatine/creatinine, acetoacetate, alanine, citrate, 2-ketoglutarate, succinate, lactate, and hippurate.
This study demonstrates metabolic similarities between the two stages of T2DM, including reduced tricarboxylic acid (TCA) cycle and increased ketone bodies production.
In addition, compared with Zucker obese rats, the GK rats have enhanced concentration of energy metabolites, which indicates energy metabolic changes produced in hyperglycemia stage more than in insulin resistance stage.
American Psychological Association (APA)
Zhao, Liang-Cai& Zhang, Xiao-Dong& Liao, Shi-Xian& Gao, Hong-Chang& Wang, He-Yao& Lin, Dong-Hai. 2010. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-471792
Modern Language Association (MLA)
Zhao, Liang-Cai…[et al.]. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-471792
American Medical Association (AMA)
Zhao, Liang-Cai& Zhang, Xiao-Dong& Liao, Shi-Xian& Gao, Hong-Chang& Wang, He-Yao& Lin, Dong-Hai. A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-471792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471792