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Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism
المؤلفون المشاركون
Paccagnini, Eugenio
Durand, Thierry
Gentile, Mariangela
Guerranti, Roberto
Rossi, Marcello
Hayek, Joussef
Pecorelli, Alessandra
Leoncini, Silvia
Cortelazzo, Alessio
Zollo, Gloria
Signorini, Cinzia
Belmonte, Giuseppe
Ciccoli, Lucia
De Felice, Claudio
Giuseppe, Valacchi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Autism spectrum disorders (ASDs) are a complex group of neurodevelopment disorders steadily rising in frequency and treatment refractory, where the search for biological markers is of paramount importance.
Although red blood cells (RBCs) membrane lipidomics and rheological variables have been reported to be altered, with some suggestions indicating an increased lipid peroxidation in the erythrocyte membrane, to date no information exists on how the oxidative membrane damage may affect cytoskeletal membrane proteins and, ultimately, RBCs shape in autism.
Here, we investigated RBC morphology by scanning electron microscopy in patients with classical autism, that is, the predominant ASDs phenotype (age range: 6–26 years), nonautistic neurodevelopmental disorders (i.e., “positive controls”), and healthy controls (i.e., “negative controls”).
A high percentage of altered RBCs shapes, predominantly elliptocytes, was observed in autistic patients, but not in both control groups.
The RBCs altered morphology in autistic subjects was related to increased erythrocyte membrane F2-isoprostanes and 4-hydroxynonenal protein adducts.
In addition, an oxidative damage of the erythrocyte membrane β-actin protein was evidenced.
Therefore, the combination of erythrocyte shape abnormalities, erythrocyte membrane oxidative damage, and β-actin alterations constitutes a previously unrecognized triad in classical autism and provides new biological markers in the diagnostic workup of ASDs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ciccoli, Lucia& De Felice, Claudio& Paccagnini, Eugenio& Leoncini, Silvia& Pecorelli, Alessandra& Signorini, Cinzia…[et al.]. 2013. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471867
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ciccoli, Lucia…[et al.]. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-471867
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ciccoli, Lucia& De Felice, Claudio& Paccagnini, Eugenio& Leoncini, Silvia& Pecorelli, Alessandra& Signorini, Cinzia…[et al.]. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471867
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471867
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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