Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism
Joint Authors
Paccagnini, Eugenio
Durand, Thierry
Gentile, Mariangela
Guerranti, Roberto
Rossi, Marcello
Hayek, Joussef
Pecorelli, Alessandra
Leoncini, Silvia
Cortelazzo, Alessio
Zollo, Gloria
Signorini, Cinzia
Belmonte, Giuseppe
Ciccoli, Lucia
De Felice, Claudio
Giuseppe, Valacchi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Autism spectrum disorders (ASDs) are a complex group of neurodevelopment disorders steadily rising in frequency and treatment refractory, where the search for biological markers is of paramount importance.
Although red blood cells (RBCs) membrane lipidomics and rheological variables have been reported to be altered, with some suggestions indicating an increased lipid peroxidation in the erythrocyte membrane, to date no information exists on how the oxidative membrane damage may affect cytoskeletal membrane proteins and, ultimately, RBCs shape in autism.
Here, we investigated RBC morphology by scanning electron microscopy in patients with classical autism, that is, the predominant ASDs phenotype (age range: 6–26 years), nonautistic neurodevelopmental disorders (i.e., “positive controls”), and healthy controls (i.e., “negative controls”).
A high percentage of altered RBCs shapes, predominantly elliptocytes, was observed in autistic patients, but not in both control groups.
The RBCs altered morphology in autistic subjects was related to increased erythrocyte membrane F2-isoprostanes and 4-hydroxynonenal protein adducts.
In addition, an oxidative damage of the erythrocyte membrane β-actin protein was evidenced.
Therefore, the combination of erythrocyte shape abnormalities, erythrocyte membrane oxidative damage, and β-actin alterations constitutes a previously unrecognized triad in classical autism and provides new biological markers in the diagnostic workup of ASDs.
American Psychological Association (APA)
Ciccoli, Lucia& De Felice, Claudio& Paccagnini, Eugenio& Leoncini, Silvia& Pecorelli, Alessandra& Signorini, Cinzia…[et al.]. 2013. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471867
Modern Language Association (MLA)
Ciccoli, Lucia…[et al.]. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-471867
American Medical Association (AMA)
Ciccoli, Lucia& De Felice, Claudio& Paccagnini, Eugenio& Leoncini, Silvia& Pecorelli, Alessandra& Signorini, Cinzia…[et al.]. Erythrocyte Shape Abnormalities, Membrane Oxidative Damage, and β-Actin Alterations : An Unrecognized Triad in Classical Autism. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-471867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471867