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Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA : Possible Role in Proliferative Diabetic Retinopathy
المؤلفون المشاركون
Nussbaum, Julian J.
Matragoon, Suraporn
Kumar, Parag
Elshaer, Sally L.
Abdelsaid, Mohammed A.
al-Azayzih, Ahmad
El-Remessy, Azza B.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Proliferative diabetic retinopathy (PDR) is the leading cause of blindness in working age Americans.
We demonstrated that diabetes disturbs the homeostasis of nerve growth factor (NGF) resulting in accumulation of its precursor proNGF.
Increases in proNGF were positively correlated with progression of diabetic retinopathy, having the highest level in ocular fluids from PDR patients compared to nondiabetic patients.
Here, we attempted to evaluate the contribution and the possible mechanism of proNGF to PDR.
The angiogenic response of aqueous humor samples from PDR patients was examined in human retinal endothelial cells in the presence or absence of anti-proNGF antibody.
Additional cultures were treated with mutant-proNGF in the presence of specific pharmacological inhibitors of TrkA and p75NTR receptors.
PDR-aqueous humor samples exerted significant angiogenic response including cell proliferation, migration, and alignment into tube-like structures.
These effects were significantly reduced by anti-proNGF antibody but not by IgG.
Treatment of retinal endothelial cells with mutant-proNGF activated phosphorylation of TrkA and p38MAPK; however, it did not alter p75NTR expression.
Inhibition of TrkA but not p75NTR significantly reduced mutant-proNGF-induced cell proliferation, cell migration, and tube formation.
Taken together, these results provide evidence that proNGF can contribute to PDR at least in part via activation of TrkA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Elshaer, Sally L.& Abdelsaid, Mohammed A.& al-Azayzih, Ahmad& Kumar, Parag& Matragoon, Suraporn& Nussbaum, Julian J.…[et al.]. 2013. Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA : Possible Role in Proliferative Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Elshaer, Sally L.…[et al.]. Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA : Possible Role in Proliferative Diabetic Retinopathy. Journal of Diabetes Research No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-471873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Elshaer, Sally L.& Abdelsaid, Mohammed A.& al-Azayzih, Ahmad& Kumar, Parag& Matragoon, Suraporn& Nussbaum, Julian J.…[et al.]. Pronerve Growth Factor Induces Angiogenesis via Activation of TrkA : Possible Role in Proliferative Diabetic Retinopathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-471873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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