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Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs
المؤلفون المشاركون
Dantas Cassali, Geovanni
Rocha, Rafael Malagoli
Cavalheiro Bertagnolli, Angélica
Ribeiro, Gustavo Meirelles
المصدر
Veterinary Medicine International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Carcinoma in benign-mixed tumor (CBMT) is common in the female canine mammary gland and comprises malignant epithelial between benign mesenchymal elements.
This study investigated the morphological aspects of 29 CBMT and their immunophenotypical profiles, by using an immunohistochemistry panel based on five molecular markers—estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), cytokeratin 5 (CK5), and human epidermal growth factor receptor 1 (EGFR).
From these, CBMT was classified into four subtypes: luminal A, luminal B, HER2-like, basal-like, and normal.
“In situ” and invasive carcinomatous components were analyzed and compared.
Histological grade I carcinoma was observed in 16 cases (55.2%) of the tumors analyzed, grade II in 10 cases (34.5%), and grade III in three cases (10.3%).
The invasive carcinomatous component has shown, more frequently, luminal A (12/29 cases, 41.4%), followed by basal-like phenotype (8/29 cases, 27.6%).
There was high concordance between immunophenotypical profiles of the in situ and invasive carcinomatous components (kappa coefficient = 0.816, P<0.001).
We concluded that CBMT predominantly has features of low-grade neoplasms of malignancy.
The various immunophenotypic profiles suggest the origin of these lesions in more than one cell type (luminal and myoepithelial).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribeiro, Gustavo Meirelles& Cavalheiro Bertagnolli, Angélica& Rocha, Rafael Malagoli& Dantas Cassali, Geovanni. 2012. Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs. Veterinary Medicine International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-471886
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribeiro, Gustavo Meirelles…[et al.]. Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs. Veterinary Medicine International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-471886
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribeiro, Gustavo Meirelles& Cavalheiro Bertagnolli, Angélica& Rocha, Rafael Malagoli& Dantas Cassali, Geovanni. Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs. Veterinary Medicine International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-471886
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471886
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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