Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs
Joint Authors
Dantas Cassali, Geovanni
Rocha, Rafael Malagoli
Cavalheiro Bertagnolli, Angélica
Ribeiro, Gustavo Meirelles
Source
Veterinary Medicine International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Carcinoma in benign-mixed tumor (CBMT) is common in the female canine mammary gland and comprises malignant epithelial between benign mesenchymal elements.
This study investigated the morphological aspects of 29 CBMT and their immunophenotypical profiles, by using an immunohistochemistry panel based on five molecular markers—estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), cytokeratin 5 (CK5), and human epidermal growth factor receptor 1 (EGFR).
From these, CBMT was classified into four subtypes: luminal A, luminal B, HER2-like, basal-like, and normal.
“In situ” and invasive carcinomatous components were analyzed and compared.
Histological grade I carcinoma was observed in 16 cases (55.2%) of the tumors analyzed, grade II in 10 cases (34.5%), and grade III in three cases (10.3%).
The invasive carcinomatous component has shown, more frequently, luminal A (12/29 cases, 41.4%), followed by basal-like phenotype (8/29 cases, 27.6%).
There was high concordance between immunophenotypical profiles of the in situ and invasive carcinomatous components (kappa coefficient = 0.816, P<0.001).
We concluded that CBMT predominantly has features of low-grade neoplasms of malignancy.
The various immunophenotypic profiles suggest the origin of these lesions in more than one cell type (luminal and myoepithelial).
American Psychological Association (APA)
Ribeiro, Gustavo Meirelles& Cavalheiro Bertagnolli, Angélica& Rocha, Rafael Malagoli& Dantas Cassali, Geovanni. 2012. Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs. Veterinary Medicine International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-471886
Modern Language Association (MLA)
Ribeiro, Gustavo Meirelles…[et al.]. Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs. Veterinary Medicine International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-471886
American Medical Association (AMA)
Ribeiro, Gustavo Meirelles& Cavalheiro Bertagnolli, Angélica& Rocha, Rafael Malagoli& Dantas Cassali, Geovanni. Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs. Veterinary Medicine International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-471886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471886