Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
المؤلفون المشاركون
Li, Ji
Tang, Minzhong
Winkler, Cheryl A.
de Thé, Guy
Guan, Li
Zeng, Yi
Guo, Xiuchan
O’Brien, Stephen J.
Deng, Hong
Liao, Jian
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC).
A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC.
To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted.
Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped.
To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC).
Results.
The reported associations between ITGA9 variants and NPC were not replicated.
Multiple loci of GABBR1, HLA-F, HLA-A, and HCG9 were statistically significant in both cohorts (Pcombined range from 5.96 × 10−17 to 0.02).
We show for the first time that these factors influence NPC development independent of environmental risk factors.
This study also indicated that the SNP alone cannot serve as a predictive/diagnostic marker for NPC.
Integrating the most significant SNP with IgA antibodies status to EBV, which is presently used as screening/diagnostic marker for NPC in Chinese populations, did not improve the AUC estimate for diagnosis of NPC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Xiuchan& Winkler, Cheryl A.& Li, Ji& Guan, Li& Tang, Minzhong& Liao, Jian…[et al.]. 2014. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471923
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Xiuchan…[et al.]. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471923
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Xiuchan& Winkler, Cheryl A.& Li, Ji& Guan, Li& Tang, Minzhong& Liao, Jian…[et al.]. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471923
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-471923
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر