Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
Joint Authors
Li, Ji
Tang, Minzhong
Winkler, Cheryl A.
de Thé, Guy
Guan, Li
Zeng, Yi
Guo, Xiuchan
O’Brien, Stephen J.
Deng, Hong
Liao, Jian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC).
A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC.
To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted.
Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped.
To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic role of significant SNPs by calculating the area under the curve (AUC).
Results.
The reported associations between ITGA9 variants and NPC were not replicated.
Multiple loci of GABBR1, HLA-F, HLA-A, and HCG9 were statistically significant in both cohorts (Pcombined range from 5.96 × 10−17 to 0.02).
We show for the first time that these factors influence NPC development independent of environmental risk factors.
This study also indicated that the SNP alone cannot serve as a predictive/diagnostic marker for NPC.
Integrating the most significant SNP with IgA antibodies status to EBV, which is presently used as screening/diagnostic marker for NPC in Chinese populations, did not improve the AUC estimate for diagnosis of NPC.
American Psychological Association (APA)
Guo, Xiuchan& Winkler, Cheryl A.& Li, Ji& Guan, Li& Tang, Minzhong& Liao, Jian…[et al.]. 2014. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471923
Modern Language Association (MLA)
Guo, Xiuchan…[et al.]. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-471923
American Medical Association (AMA)
Guo, Xiuchan& Winkler, Cheryl A.& Li, Ji& Guan, Li& Tang, Minzhong& Liao, Jian…[et al.]. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-471923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-471923