![](/images/graphics-bg.png)
The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors
المؤلفون المشاركون
Lin, Chiao-Wen
Tang, Chih-Hsin
Cheng, Hsu-Chen
Yang, Shun-Fa
Chen, Po-Chun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The CCN family of proteins is composed of six extracellular matrix-associated proteins that play crucial roles in skeletal development, wound healing, fibrosis, and cancer.
Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion, migration, proliferation, differentiation, and survival through direct binding to specific integrin receptors and heparan sulfate proteoglycans.
In the present review, we discuss the roles of the CCN family proteins in regulating resident cells of the bone microenvironment.
In vertebrate development, the CCN family plays a critical role in osteo/chondrogenesis and vasculo/angiogenesis.
These effects are regulated through signaling via integrins, bone morphogenetic protein, vascular endothelial growth factor, Wnt, and Notch via direct binding to CCN family proteins.
Due to the important roles of CCN family proteins in skeletal development, abnormal expression of CCN proteins is related to the tumorigenesis of primary bone tumors such as osteosarcoma, Ewing sarcoma, and chondrosarcoma.
Additionally, emerging studies have suggested that CCN proteins may affect progression of secondary metastatic bone tumors by moderating the bone microenvironment.
CCN proteins could therefore serve as potential therapeutic targets for drug development against primary and metastatic bone tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Po-Chun& Cheng, Hsu-Chen& Yang, Shun-Fa& Lin, Chiao-Wen& Tang, Chih-Hsin. 2014. The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-472217
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Po-Chun…[et al.]. The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-472217
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Po-Chun& Cheng, Hsu-Chen& Yang, Shun-Fa& Lin, Chiao-Wen& Tang, Chih-Hsin. The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-472217
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472217
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)