The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors

Joint Authors

Lin, Chiao-Wen
Tang, Chih-Hsin
Cheng, Hsu-Chen
Yang, Shun-Fa
Chen, Po-Chun

Source

BioMed Research International

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-01-14

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

The CCN family of proteins is composed of six extracellular matrix-associated proteins that play crucial roles in skeletal development, wound healing, fibrosis, and cancer.

Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion, migration, proliferation, differentiation, and survival through direct binding to specific integrin receptors and heparan sulfate proteoglycans.

In the present review, we discuss the roles of the CCN family proteins in regulating resident cells of the bone microenvironment.

In vertebrate development, the CCN family plays a critical role in osteo/chondrogenesis and vasculo/angiogenesis.

These effects are regulated through signaling via integrins, bone morphogenetic protein, vascular endothelial growth factor, Wnt, and Notch via direct binding to CCN family proteins.

Due to the important roles of CCN family proteins in skeletal development, abnormal expression of CCN proteins is related to the tumorigenesis of primary bone tumors such as osteosarcoma, Ewing sarcoma, and chondrosarcoma.

Additionally, emerging studies have suggested that CCN proteins may affect progression of secondary metastatic bone tumors by moderating the bone microenvironment.

CCN proteins could therefore serve as potential therapeutic targets for drug development against primary and metastatic bone tumors.

American Psychological Association (APA)

Chen, Po-Chun& Cheng, Hsu-Chen& Yang, Shun-Fa& Lin, Chiao-Wen& Tang, Chih-Hsin. 2014. The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-472217

Modern Language Association (MLA)

Chen, Po-Chun…[et al.]. The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-472217

American Medical Association (AMA)

Chen, Po-Chun& Cheng, Hsu-Chen& Yang, Shun-Fa& Lin, Chiao-Wen& Tang, Chih-Hsin. The CCN Family Proteins : Modulators of Bone Development and Novel Targets in Bone-Associated Tumors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-472217

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-472217