Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV)‎ Complexes of Schiff Base and Phenanthroline

المؤلفون المشاركون

Zhang, Yongli
Fang, Wei
Cai, Xiaoyan
Chu, Fu Jiang
Lu, Jiazheng
Wang, Xiangsheng
Liao, Xiangwen

المصدر

Bioinorganic Chemistry and Applications

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-01-29

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء

الملخص EN

Two oxovanadium(IV) complexes of [VO(msatsc)(phen)], (1) (msatsc = methoxylsalicylaldehyde thiosemicarbazone, phen = phenanthroline) and its novel derivative [VO (4-chlorosatsc)(phen)], (2) (4-chlorosatsc = 4-chlorosalicylaldehyde thiosemicarbazone), have been synthesized and characterized by elemental analysis, IR, ES-MS, 1H NMR, and magnetic susceptibility measurements.

Their antitumor effects on BEL-7402, HUH-7, and HepG2 cells were studied by MTT assay.

The antitumor biological mechanism of these two complexes was studied in BEL-7402 cells by cell cycle analysis, Hoechst 33342 staining, Annexin V-FITC/PI assay, and detection of mitochondrial membrane potential (ΔΨm).

The results showed that the growth of cancer cells was inhibited significantly, and complexes 1 and 2 mainly caused in BEL-7402 cells G0/G1 cell cycle arrest and induced apoptosis.

Both 1 and 2 decreased significantly the ΔΨm, causing the depolarization of the mitochondrial membrane.

Complex 2 showed greater antitumor efficiency than that of complex 1.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Yongli& Wang, Xiangsheng& Fang, Wei& Cai, Xiaoyan& Chu, Fu Jiang& Liao, Xiangwen…[et al.]. 2013. Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-472222

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Yongli…[et al.]. Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-472222

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Yongli& Wang, Xiangsheng& Fang, Wei& Cai, Xiaoyan& Chu, Fu Jiang& Liao, Xiangwen…[et al.]. Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-472222

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-472222