Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline
Joint Authors
Zhang, Yongli
Fang, Wei
Cai, Xiaoyan
Chu, Fu Jiang
Lu, Jiazheng
Wang, Xiangsheng
Liao, Xiangwen
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Two oxovanadium(IV) complexes of [VO(msatsc)(phen)], (1) (msatsc = methoxylsalicylaldehyde thiosemicarbazone, phen = phenanthroline) and its novel derivative [VO (4-chlorosatsc)(phen)], (2) (4-chlorosatsc = 4-chlorosalicylaldehyde thiosemicarbazone), have been synthesized and characterized by elemental analysis, IR, ES-MS, 1H NMR, and magnetic susceptibility measurements.
Their antitumor effects on BEL-7402, HUH-7, and HepG2 cells were studied by MTT assay.
The antitumor biological mechanism of these two complexes was studied in BEL-7402 cells by cell cycle analysis, Hoechst 33342 staining, Annexin V-FITC/PI assay, and detection of mitochondrial membrane potential (ΔΨm).
The results showed that the growth of cancer cells was inhibited significantly, and complexes 1 and 2 mainly caused in BEL-7402 cells G0/G1 cell cycle arrest and induced apoptosis.
Both 1 and 2 decreased significantly the ΔΨm, causing the depolarization of the mitochondrial membrane.
Complex 2 showed greater antitumor efficiency than that of complex 1.
American Psychological Association (APA)
Zhang, Yongli& Wang, Xiangsheng& Fang, Wei& Cai, Xiaoyan& Chu, Fu Jiang& Liao, Xiangwen…[et al.]. 2013. Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-472222
Modern Language Association (MLA)
Zhang, Yongli…[et al.]. Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-472222
American Medical Association (AMA)
Zhang, Yongli& Wang, Xiangsheng& Fang, Wei& Cai, Xiaoyan& Chu, Fu Jiang& Liao, Xiangwen…[et al.]. Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-472222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472222