Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis
المؤلفون المشاركون
Qi, Yunpeng
Song, Yunlong
Chai, Yifeng
Dong, Xin
Fan, Guorong
Lou, Ziyang
Gu, Haiwei
Liu, Aijun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Resina draconis (bright red resin isolated from Dracaena cochinchinensis, RD) has been clinically used for treatment of myocardial ischemia (MI) for many years.
However, the mechanisms of its pharmacological action on MI are still poorly understood.
This study aimed to characterize the plasma metabolic profiles of MI and investigate the mechanisms of RD on MI using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry-based metabolomics combined with pattern recognition methods and metabolic pathway analysis.
Twenty metabolite markers characterizing metabolic profile of MI were revealed, which were mainly involved in aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine, and tryptophan biosynthesis, vascular smooth muscle contraction, sphingolipid metabolism, and so forth.
After RD treatment, however, levels of seven MI metabolite markers, including phytosphingosine, sphinganine, acetylcarnitine, cGMP, cAMP, L-tyrosine, and L-valine, were turned over, indicating that RD is likely to alleviate MI through regulating the disturbed vascular smooth muscle contraction, sphingolipid metabolism, phenylalanine metabolism, and BCAA metabolism.
To our best knowledge, this is the first comprehensive study to investigate the mechanisms of RD for treating MI, from a metabolomics point of view.
Our findings are very valuable to gain a better understanding of MI metabolic profiles and provide novel insights for exploring the mechanisms of RD on MI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qi, Yunpeng& Gu, Haiwei& Song, Yunlong& Dong, Xin& Liu, Aijun& Lou, Ziyang…[et al.]. 2013. Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qi, Yunpeng…[et al.]. Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qi, Yunpeng& Gu, Haiwei& Song, Yunlong& Dong, Xin& Liu, Aijun& Lou, Ziyang…[et al.]. Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر