Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis
Joint Authors
Qi, Yunpeng
Song, Yunlong
Chai, Yifeng
Dong, Xin
Fan, Guorong
Lou, Ziyang
Gu, Haiwei
Liu, Aijun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Resina draconis (bright red resin isolated from Dracaena cochinchinensis, RD) has been clinically used for treatment of myocardial ischemia (MI) for many years.
However, the mechanisms of its pharmacological action on MI are still poorly understood.
This study aimed to characterize the plasma metabolic profiles of MI and investigate the mechanisms of RD on MI using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry-based metabolomics combined with pattern recognition methods and metabolic pathway analysis.
Twenty metabolite markers characterizing metabolic profile of MI were revealed, which were mainly involved in aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine, and tryptophan biosynthesis, vascular smooth muscle contraction, sphingolipid metabolism, and so forth.
After RD treatment, however, levels of seven MI metabolite markers, including phytosphingosine, sphinganine, acetylcarnitine, cGMP, cAMP, L-tyrosine, and L-valine, were turned over, indicating that RD is likely to alleviate MI through regulating the disturbed vascular smooth muscle contraction, sphingolipid metabolism, phenylalanine metabolism, and BCAA metabolism.
To our best knowledge, this is the first comprehensive study to investigate the mechanisms of RD for treating MI, from a metabolomics point of view.
Our findings are very valuable to gain a better understanding of MI metabolic profiles and provide novel insights for exploring the mechanisms of RD on MI.
American Psychological Association (APA)
Qi, Yunpeng& Gu, Haiwei& Song, Yunlong& Dong, Xin& Liu, Aijun& Lou, Ziyang…[et al.]. 2013. Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472374
Modern Language Association (MLA)
Qi, Yunpeng…[et al.]. Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472374
American Medical Association (AMA)
Qi, Yunpeng& Gu, Haiwei& Song, Yunlong& Dong, Xin& Liu, Aijun& Lou, Ziyang…[et al.]. Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid ChromatographyQuadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472374
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472374