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Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence
المؤلفون المشاركون
Opara, Franklin
Des-Vignes-Kendrick, M.
Hossain, Jobayer
Holmes, Laurens
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Sex disparities in pediatric leukemia have been previously reported, and male children continue to present with poorer survival.
However, the observed disparities are not fully understood.
This current study sought to examine disparities in survival by the sex, and to determine if tumor prognostic factors impact on these disparities.
Patients and Methods.
We used the Surveillance Epidemiology and End Results dataset of pediatric leukemia patients (ages 0–19 years) diagnosed in the United States from 1973 to 2006.
There were 15,215 patients of whom 8,622 (65.7%) were boys and 6,593 (43.3%) were girls.
The Kaplan-Meier survival estimates, log rank test, and Cox proportional hazard methods were used to assess the data.
Results.
The overall (both sexes) five-year survival rate was 67.9%.
Girls had a survival rate of 70.1%, while the rate was 66.3% in boys.
Girls had a significant 14% decreased risk of dying relative to boys, hazard ratio (HR) = 0.86, 99% CI = 0.80–0.93.
There were significant differences between boys and girls with respect to tumor cell type, race, age at diagnosis, year of diagnosis, and number of primaries, P<0.001.
After controlling for these factors, the sex differences in survival persisted, with girls still less likely to die from leukemia compared to boys, adjusted HR (AHR) = 0.85, 99% CI = 0.72–1.00, P<0.01.
Conclusion.
In a large population-based pediatric leukemia study, boys continued to show poorer survival.
These disparities were not completely explained by treatment received, tumor prognostic or socio-demographic factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Holmes, Laurens& Hossain, Jobayer& Des-Vignes-Kendrick, M.& Opara, Franklin. 2012. Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence. ISRN Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472409
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Holmes, Laurens…[et al.]. Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence. ISRN Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472409
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Holmes, Laurens& Hossain, Jobayer& Des-Vignes-Kendrick, M.& Opara, Franklin. Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472409
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472409
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