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Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence
Joint Authors
Opara, Franklin
Des-Vignes-Kendrick, M.
Hossain, Jobayer
Holmes, Laurens
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Sex disparities in pediatric leukemia have been previously reported, and male children continue to present with poorer survival.
However, the observed disparities are not fully understood.
This current study sought to examine disparities in survival by the sex, and to determine if tumor prognostic factors impact on these disparities.
Patients and Methods.
We used the Surveillance Epidemiology and End Results dataset of pediatric leukemia patients (ages 0–19 years) diagnosed in the United States from 1973 to 2006.
There were 15,215 patients of whom 8,622 (65.7%) were boys and 6,593 (43.3%) were girls.
The Kaplan-Meier survival estimates, log rank test, and Cox proportional hazard methods were used to assess the data.
Results.
The overall (both sexes) five-year survival rate was 67.9%.
Girls had a survival rate of 70.1%, while the rate was 66.3% in boys.
Girls had a significant 14% decreased risk of dying relative to boys, hazard ratio (HR) = 0.86, 99% CI = 0.80–0.93.
There were significant differences between boys and girls with respect to tumor cell type, race, age at diagnosis, year of diagnosis, and number of primaries, P<0.001.
After controlling for these factors, the sex differences in survival persisted, with girls still less likely to die from leukemia compared to boys, adjusted HR (AHR) = 0.85, 99% CI = 0.72–1.00, P<0.01.
Conclusion.
In a large population-based pediatric leukemia study, boys continued to show poorer survival.
These disparities were not completely explained by treatment received, tumor prognostic or socio-demographic factors.
American Psychological Association (APA)
Holmes, Laurens& Hossain, Jobayer& Des-Vignes-Kendrick, M.& Opara, Franklin. 2012. Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence. ISRN Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472409
Modern Language Association (MLA)
Holmes, Laurens…[et al.]. Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence. ISRN Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472409
American Medical Association (AMA)
Holmes, Laurens& Hossain, Jobayer& Des-Vignes-Kendrick, M.& Opara, Franklin. Sex Variability in Pediatric Leukemia Survival : Large Cohort Evidence. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472409