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Thermoanalytical Investigation of Some Sulfone-Containing Drugs
المؤلفون المشاركون
Abd El Hamid, Maha
Toubar, Safaa
El Ries, Mohammed A.
Walash, Mohammed I.
Salama, Nahla N.
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The thermal behavior of some sulfone-containing drugs, namely, dapsone (DDS), dimethylsulfone (MSM), and topiramate (TOP) in drug substances, and products were investigated using different thermal techniques.
These include thermogravimetry (TGA), derivative thermogravimetry (DTG), differential thermal analysis (DTA), and differential scanning calorimetry (DSC).
The thermogravimetric data allowed the determination of the kinetic parameters: activation energy (Ea), frequency factor (A), and reaction order (n).
The thermal degradation of dapsone and topiramate was followed a first-order kinetic behavior.
The calculated data evidenced a zero-order kinetic for dimethylsulfone.
The relative thermal stabilities of the studied drugs have been evaluated and follow the order DDS > TOP > MSM.
The purity was determined using DSC for the studied compounds, in drug substances and products.
The results were in agreement with the recommended pharmacopoeia and manufacturer methods.
DSC curves obtained from the tablets suggest compatibility between the drugs, excipients and/or coformulated drugs.
The fragmentation pathway of dapsone with mass spectrometry was taken as example, to correlate the thermal decomposition with the resulted MS-EI.
The decomposition modes were investigated, and the possible fragmentation pathways were suggested by mass spectrometry.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salama, Nahla N.& El Ries, Mohammed A.& Toubar, Safaa& Abd El Hamid, Maha& Walash, Mohammed I.. 2012. Thermoanalytical Investigation of Some Sulfone-Containing Drugs. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salama, Nahla N.…[et al.]. Thermoanalytical Investigation of Some Sulfone-Containing Drugs. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salama, Nahla N.& El Ries, Mohammed A.& Toubar, Safaa& Abd El Hamid, Maha& Walash, Mohammed I.. Thermoanalytical Investigation of Some Sulfone-Containing Drugs. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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