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Thermoanalytical Investigation of Some Sulfone-Containing Drugs
Joint Authors
Abd El Hamid, Maha
Toubar, Safaa
El Ries, Mohammed A.
Walash, Mohammed I.
Salama, Nahla N.
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The thermal behavior of some sulfone-containing drugs, namely, dapsone (DDS), dimethylsulfone (MSM), and topiramate (TOP) in drug substances, and products were investigated using different thermal techniques.
These include thermogravimetry (TGA), derivative thermogravimetry (DTG), differential thermal analysis (DTA), and differential scanning calorimetry (DSC).
The thermogravimetric data allowed the determination of the kinetic parameters: activation energy (Ea), frequency factor (A), and reaction order (n).
The thermal degradation of dapsone and topiramate was followed a first-order kinetic behavior.
The calculated data evidenced a zero-order kinetic for dimethylsulfone.
The relative thermal stabilities of the studied drugs have been evaluated and follow the order DDS > TOP > MSM.
The purity was determined using DSC for the studied compounds, in drug substances and products.
The results were in agreement with the recommended pharmacopoeia and manufacturer methods.
DSC curves obtained from the tablets suggest compatibility between the drugs, excipients and/or coformulated drugs.
The fragmentation pathway of dapsone with mass spectrometry was taken as example, to correlate the thermal decomposition with the resulted MS-EI.
The decomposition modes were investigated, and the possible fragmentation pathways were suggested by mass spectrometry.
American Psychological Association (APA)
Salama, Nahla N.& El Ries, Mohammed A.& Toubar, Safaa& Abd El Hamid, Maha& Walash, Mohammed I.. 2012. Thermoanalytical Investigation of Some Sulfone-Containing Drugs. Journal of Analytical Methods in Chemistry،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472413
Modern Language Association (MLA)
Salama, Nahla N.…[et al.]. Thermoanalytical Investigation of Some Sulfone-Containing Drugs. Journal of Analytical Methods in Chemistry No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-472413
American Medical Association (AMA)
Salama, Nahla N.& El Ries, Mohammed A.& Toubar, Safaa& Abd El Hamid, Maha& Walash, Mohammed I.. Thermoanalytical Investigation of Some Sulfone-Containing Drugs. Journal of Analytical Methods in Chemistry. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-472413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472413