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The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators
المؤلفون المشاركون
Kyriakopoulou, Magdalini
Tsaganos, Thomas
Giamarellos-Bourboulis, Evangelos J.
Antonopoulou, Anastasia
Raftogiannis, Maria
Kanellakopoulou, Kyriaki
Baziaka, Fotini
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-03-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To clarify whether time lapsing from advent of fever as a first sign of sepsis may be indicative of the potency of monocytes for the release of pro- and anti-inflammatory mediators.
Methods.
Monocytes were isolated from blood of 51 septic patients and 9 healthy donors.
Monocytes were incubated in the absence and presence of patients' serum and concentrations of tumour necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-10, and malondialdehyde (MDA) were estimated in supernatants.
Patients were divided into three groups: group A: <12 hours; group B: 12–24 hours, and group C: >24 hours between initiation of fever and blood sampling.
Results.
TNFα of supernatants of groups B and C was higher than controls, as also were IL-6 of A and C, IL-10 of A and B, and MDA of A.
IL-6 of group A was increased after addition of patients serum.
A negative correlation was found between time from initiation of symptoms and IL-6 of monocyte supernatants incubated in the presence of patients serum.
Median IL-6 of survivors was higher than nonsurvivors.
Conclusion.
Monocytes are potent for the release of pro- and anti-inflammatory mediators within the first 24 hours upon advent of fever related to sepsis; serum stimulates further release of IL-6 within the first 12 hours.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kyriakopoulou, Magdalini& Antonopoulou, Anastasia& Raftogiannis, Maria& Baziaka, Fotini& Tsaganos, Thomas& Kanellakopoulou, Kyriaki…[et al.]. 2008. The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-472511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kyriakopoulou, Magdalini…[et al.]. The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators. Mediators of Inflammation No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-472511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kyriakopoulou, Magdalini& Antonopoulou, Anastasia& Raftogiannis, Maria& Baziaka, Fotini& Tsaganos, Thomas& Kanellakopoulou, Kyriaki…[et al.]. The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-472511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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