![](/images/graphics-bg.png)
The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators
Joint Authors
Kyriakopoulou, Magdalini
Tsaganos, Thomas
Giamarellos-Bourboulis, Evangelos J.
Antonopoulou, Anastasia
Raftogiannis, Maria
Kanellakopoulou, Kyriaki
Baziaka, Fotini
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To clarify whether time lapsing from advent of fever as a first sign of sepsis may be indicative of the potency of monocytes for the release of pro- and anti-inflammatory mediators.
Methods.
Monocytes were isolated from blood of 51 septic patients and 9 healthy donors.
Monocytes were incubated in the absence and presence of patients' serum and concentrations of tumour necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-10, and malondialdehyde (MDA) were estimated in supernatants.
Patients were divided into three groups: group A: <12 hours; group B: 12–24 hours, and group C: >24 hours between initiation of fever and blood sampling.
Results.
TNFα of supernatants of groups B and C was higher than controls, as also were IL-6 of A and C, IL-10 of A and B, and MDA of A.
IL-6 of group A was increased after addition of patients serum.
A negative correlation was found between time from initiation of symptoms and IL-6 of monocyte supernatants incubated in the presence of patients serum.
Median IL-6 of survivors was higher than nonsurvivors.
Conclusion.
Monocytes are potent for the release of pro- and anti-inflammatory mediators within the first 24 hours upon advent of fever related to sepsis; serum stimulates further release of IL-6 within the first 12 hours.
American Psychological Association (APA)
Kyriakopoulou, Magdalini& Antonopoulou, Anastasia& Raftogiannis, Maria& Baziaka, Fotini& Tsaganos, Thomas& Kanellakopoulou, Kyriaki…[et al.]. 2008. The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-472511
Modern Language Association (MLA)
Kyriakopoulou, Magdalini…[et al.]. The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators. Mediators of Inflammation No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-472511
American Medical Association (AMA)
Kyriakopoulou, Magdalini& Antonopoulou, Anastasia& Raftogiannis, Maria& Baziaka, Fotini& Tsaganos, Thomas& Kanellakopoulou, Kyriaki…[et al.]. The Importance of Fever as a Predictive Symptom for the Potency of Host's Monocytes to Release Pro- and Anti-Inflammatory Mediators. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-472511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472511