Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells
المؤلفون المشاركون
Kim, Se-Kwon
Je, Jae-Young
Jung, Won-Kyo
Qian, Zhong-Ji
Zhang, Chen
Li, Yong-Xin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Alcohol-induced liver injury progresses from fatty infiltration followed by a harmful cause of inflammation leading to an irreversible damage.
In this study, two compounds (emodin and chrysophanol) isolated from marine fungus Aspergillus sp.
were examined for their protective effects against ethanol-induced toxicity in vitro.
Ethanol-induced HepG2/CYP2E1 cells were treated with the compounds at various concentrations, and the results showed that there was a dose-dependent decrease of gamma-glutamyl transpeptidase (GGT) activity and increase of glutathione (GSH) in the culture media with an increase in cell viability.
Furthermore, the protective effects of the compounds were evaluated by protein expression levels of GGT, GSH, and CYP2E1 using Western blot.
Among the compounds, emodin addressed to the ethanol-induced cytotoxicity more effectively compared to the chrysophanol.
It could be suggested that emodin isolated from this genus would be a potential candidate for attenuating ethanol induced liver damage for further industrial applications such as functional food and pharmaceutical developments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qian, Zhong-Ji& Zhang, Chen& Li, Yong-Xin& Je, Jae-Young& Kim, Se-Kwon& Jung, Won-Kyo. 2011. Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-472724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qian, Zhong-Ji…[et al.]. Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-472724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qian, Zhong-Ji& Zhang, Chen& Li, Yong-Xin& Je, Jae-Young& Kim, Se-Kwon& Jung, Won-Kyo. Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-472724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر