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Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells
Joint Authors
Kim, Se-Kwon
Je, Jae-Young
Jung, Won-Kyo
Qian, Zhong-Ji
Zhang, Chen
Li, Yong-Xin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alcohol-induced liver injury progresses from fatty infiltration followed by a harmful cause of inflammation leading to an irreversible damage.
In this study, two compounds (emodin and chrysophanol) isolated from marine fungus Aspergillus sp.
were examined for their protective effects against ethanol-induced toxicity in vitro.
Ethanol-induced HepG2/CYP2E1 cells were treated with the compounds at various concentrations, and the results showed that there was a dose-dependent decrease of gamma-glutamyl transpeptidase (GGT) activity and increase of glutathione (GSH) in the culture media with an increase in cell viability.
Furthermore, the protective effects of the compounds were evaluated by protein expression levels of GGT, GSH, and CYP2E1 using Western blot.
Among the compounds, emodin addressed to the ethanol-induced cytotoxicity more effectively compared to the chrysophanol.
It could be suggested that emodin isolated from this genus would be a potential candidate for attenuating ethanol induced liver damage for further industrial applications such as functional food and pharmaceutical developments.
American Psychological Association (APA)
Qian, Zhong-Ji& Zhang, Chen& Li, Yong-Xin& Je, Jae-Young& Kim, Se-Kwon& Jung, Won-Kyo. 2011. Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-472724
Modern Language Association (MLA)
Qian, Zhong-Ji…[et al.]. Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-472724
American Medical Association (AMA)
Qian, Zhong-Ji& Zhang, Chen& Li, Yong-Xin& Je, Jae-Young& Kim, Se-Kwon& Jung, Won-Kyo. Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2CYP2E1 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-472724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472724