Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy
المؤلفون المشاركون
Papandreou, Christos N.
Daliani, Danai D.
Kakkas, Grigorios
Vlachostergios, Panagiotis J.
Karasavvidou, Foteini
Zintzaras, Elias
Melekos, Michael D.
Patrikidou, Anna
Voutsadakis, Ioannis A.
Moutzouris, George
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP).
Patients and Methods.
70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65).
Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment.
Results and Limitations.
Membranous expression of NEP (P<0.001), cytoplasmic ET-1 (P=0.002), and cytoplasmic NFκB (P<0.001) were correlated with time to PSA relapse.
NEP was associated with ET-1 (P<0.001) and NFκB (P<0.001).
ET-1 was also correlated with NFκB (P<0.001).
NEP expression (P=0.017), pT stage (P=0.013), and SMs (P=0.036) were independent predictors of time to PSA recurrence.
Conclusions.
There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vlachostergios, Panagiotis J.& Karasavvidou, Foteini& Kakkas, Grigorios& Moutzouris, George& Patrikidou, Anna& Voutsadakis, Ioannis A.…[et al.]. 2012. Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy. Prostate Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-472746
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vlachostergios, Panagiotis J.…[et al.]. Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy. Prostate Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-472746
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vlachostergios, Panagiotis J.& Karasavvidou, Foteini& Kakkas, Grigorios& Moutzouris, George& Patrikidou, Anna& Voutsadakis, Ioannis A.…[et al.]. Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-472746
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472746
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر