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Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy
Joint Authors
Papandreou, Christos N.
Daliani, Danai D.
Kakkas, Grigorios
Vlachostergios, Panagiotis J.
Karasavvidou, Foteini
Zintzaras, Elias
Melekos, Michael D.
Patrikidou, Anna
Voutsadakis, Ioannis A.
Moutzouris, George
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP).
Patients and Methods.
70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65).
Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment.
Results and Limitations.
Membranous expression of NEP (P<0.001), cytoplasmic ET-1 (P=0.002), and cytoplasmic NFκB (P<0.001) were correlated with time to PSA relapse.
NEP was associated with ET-1 (P<0.001) and NFκB (P<0.001).
ET-1 was also correlated with NFκB (P<0.001).
NEP expression (P=0.017), pT stage (P=0.013), and SMs (P=0.036) were independent predictors of time to PSA recurrence.
Conclusions.
There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.
American Psychological Association (APA)
Vlachostergios, Panagiotis J.& Karasavvidou, Foteini& Kakkas, Grigorios& Moutzouris, George& Patrikidou, Anna& Voutsadakis, Ioannis A.…[et al.]. 2012. Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy. Prostate Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-472746
Modern Language Association (MLA)
Vlachostergios, Panagiotis J.…[et al.]. Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy. Prostate Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-472746
American Medical Association (AMA)
Vlachostergios, Panagiotis J.& Karasavvidou, Foteini& Kakkas, Grigorios& Moutzouris, George& Patrikidou, Anna& Voutsadakis, Ioannis A.…[et al.]. Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer : Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-472746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472746