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The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
المؤلفون المشاركون
Puccio, Giovanna
Bosco, Domenico
Mauro, Gaetano
De Bartolo, Matteo
Colica, Carmen
Pirritano, Domenico
Ermio, Caterina
Plastino, Massimiliano
Fava, Antonietta
Cristiano, Dario
المصدر
Journal of Neurodegenerative Diseases
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD).
Most diabetic patients have insulin resistance (IR) that is associated with compensatory hyperinsulinemia, one of the mechanisms suggested for increased AD risk in patients with DM.
Alpha-lipoic acid (ALA) is a disulfide molecule with antioxidant properties that has positive effects on glucose metabolism and IR.
This study evaluated the effect of ALA treatment (600 mg/day) on cognitive performances in AD patients with and without DM.
One hundred and twenty-six patients with AD were divided into two groups, according to DM presence (group A) or absence (group B).
Cognitive functions were assessed by MMSE, Alzheimer's Disease Assessment Scale-cognitive (ADAS-Cog), Clinician's Interview-Based Impression of Severity (CIBIC), Clinical Dementia Rating (CDR), and Alzheimer's Disease Functional and Change Scale (ADFACS).
IR was assessed by HOMA index.
At the end of the study, MMSE scores showed a significant improvement in 43% patients of group A (26 subjects) and 23% of group B (15 subjects), compared to baseline (P=.001).
Also ADAS-Cog, CIBIC, and ADFACS scores showed a significant improvement in group A versus group B.
IR was higher in group A.
Our study suggests that ALA therapy could be effective in slowing cognitive decline in patients with AD and IR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fava, Antonietta& Pirritano, Domenico& Plastino, Massimiliano& Cristiano, Dario& Puccio, Giovanna& Colica, Carmen…[et al.]. 2013. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472859
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fava, Antonietta…[et al.]. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-472859
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fava, Antonietta& Pirritano, Domenico& Plastino, Massimiliano& Cristiano, Dario& Puccio, Giovanna& Colica, Carmen…[et al.]. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472859
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472859
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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