The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease
Joint Authors
Puccio, Giovanna
Bosco, Domenico
Mauro, Gaetano
De Bartolo, Matteo
Colica, Carmen
Pirritano, Domenico
Ermio, Caterina
Plastino, Massimiliano
Fava, Antonietta
Cristiano, Dario
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD).
Most diabetic patients have insulin resistance (IR) that is associated with compensatory hyperinsulinemia, one of the mechanisms suggested for increased AD risk in patients with DM.
Alpha-lipoic acid (ALA) is a disulfide molecule with antioxidant properties that has positive effects on glucose metabolism and IR.
This study evaluated the effect of ALA treatment (600 mg/day) on cognitive performances in AD patients with and without DM.
One hundred and twenty-six patients with AD were divided into two groups, according to DM presence (group A) or absence (group B).
Cognitive functions were assessed by MMSE, Alzheimer's Disease Assessment Scale-cognitive (ADAS-Cog), Clinician's Interview-Based Impression of Severity (CIBIC), Clinical Dementia Rating (CDR), and Alzheimer's Disease Functional and Change Scale (ADFACS).
IR was assessed by HOMA index.
At the end of the study, MMSE scores showed a significant improvement in 43% patients of group A (26 subjects) and 23% of group B (15 subjects), compared to baseline (P=.001).
Also ADAS-Cog, CIBIC, and ADFACS scores showed a significant improvement in group A versus group B.
IR was higher in group A.
Our study suggests that ALA therapy could be effective in slowing cognitive decline in patients with AD and IR.
American Psychological Association (APA)
Fava, Antonietta& Pirritano, Domenico& Plastino, Massimiliano& Cristiano, Dario& Puccio, Giovanna& Colica, Carmen…[et al.]. 2013. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472859
Modern Language Association (MLA)
Fava, Antonietta…[et al.]. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-472859
American Medical Association (AMA)
Fava, Antonietta& Pirritano, Domenico& Plastino, Massimiliano& Cristiano, Dario& Puccio, Giovanna& Colica, Carmen…[et al.]. The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-472859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472859