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Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo
المؤلفون المشاركون
Efferth, Thomas
Krusche, Benjamin
Arend, Joachim
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Inhibition of angiogenesis represents one major strategy of cancer chemotherapy.
In the present investigation, we investigated the synergism of artesunate and captopril to inhibit angiogenesis.
Artesunate is an antimalarial derivative of artemisinin from the Chinese medicinal plant, Artemisia annua L., which also reveals profound anticancer activity in vitro and in vivo.
Captopril is an angiotensin I-converting (ACE) inhibitor, which is well established in Western academic medicine.
Both compounds inhibited migration of human umbilical vein endothelial cells (HUVECs) in vitro.
The combination of both drugs resulted in synergistically inhibited migration.
Whereas artesunate inhibited HUVEC growth in the XTT assay, captopril did not, indicating independent modes of action.
We established a chorioallantoic membrane (CAM) assay of quail embryos (Coturnix coturnix L.) and a computer-based evaluation routine for quantitative studies on vascularization processes in vivo.
Artesunate and captopril inhibited blood vessel formation and growth.
For the first time, we demonstrated that both drugs revealed synergistic effects when combined.
These results may also have clinical impact, since cardiovascular diseases and cancer frequently occur together in older cancer patients.
Therefore, comorbid patients may take advantage, if they take captopril to treat cardiovascular symptoms and artesunate to treat cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Krusche, Benjamin& Arend, Joachim& Efferth, Thomas. 2013. Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472890
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Krusche, Benjamin…[et al.]. Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472890
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Krusche, Benjamin& Arend, Joachim& Efferth, Thomas. Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472890
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472890
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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