Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo
Joint Authors
Efferth, Thomas
Krusche, Benjamin
Arend, Joachim
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Inhibition of angiogenesis represents one major strategy of cancer chemotherapy.
In the present investigation, we investigated the synergism of artesunate and captopril to inhibit angiogenesis.
Artesunate is an antimalarial derivative of artemisinin from the Chinese medicinal plant, Artemisia annua L., which also reveals profound anticancer activity in vitro and in vivo.
Captopril is an angiotensin I-converting (ACE) inhibitor, which is well established in Western academic medicine.
Both compounds inhibited migration of human umbilical vein endothelial cells (HUVECs) in vitro.
The combination of both drugs resulted in synergistically inhibited migration.
Whereas artesunate inhibited HUVEC growth in the XTT assay, captopril did not, indicating independent modes of action.
We established a chorioallantoic membrane (CAM) assay of quail embryos (Coturnix coturnix L.) and a computer-based evaluation routine for quantitative studies on vascularization processes in vivo.
Artesunate and captopril inhibited blood vessel formation and growth.
For the first time, we demonstrated that both drugs revealed synergistic effects when combined.
These results may also have clinical impact, since cardiovascular diseases and cancer frequently occur together in older cancer patients.
Therefore, comorbid patients may take advantage, if they take captopril to treat cardiovascular symptoms and artesunate to treat cancer.
American Psychological Association (APA)
Krusche, Benjamin& Arend, Joachim& Efferth, Thomas. 2013. Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472890
Modern Language Association (MLA)
Krusche, Benjamin…[et al.]. Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-472890
American Medical Association (AMA)
Krusche, Benjamin& Arend, Joachim& Efferth, Thomas. Synergistic Inhibition of Angiogenesis by Artesunate and Captopril In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-472890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472890