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Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress
المؤلفون المشاركون
Mchedlishvili, Tamar
Rodov, Victor
Gogia, Nunu
Sanikidze, Tamar
Enukidze, Maia
Machavariani, Marine
Vinokur, Yakov
Chkhikvishvili, Irakli
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Summer savory (Satureja hortensis L., Lamiaceae) is used in several regions of the world as a spice and folk medicine.
Anti-inflammatory and cytoprotective effects of S.
hortensis and of its rosmarinic acid-rich phenolic fraction have been demonstrated in animal trials.
However, previous studies of rosmarinic acid in cell models have yielded controversial results.
In this study, we investigated the effects of summer savory extracts on H2O2-challenged human lymphoblastoid Jurkat T cells.
LC-MS analysis confirmed the presence of rosmarinic acid and flavonoids such as hesperidin and naringin in the phenolic fraction.
Adding 25 or 50 µM of H2O2 to the cell culture caused oxidative stress, manifested as generation of superoxide and peroxyl radicals, reduced cell viability, G0/G1 arrest, and enhanced apoptosis.
This stress was significantly alleviated by the ethanolic and aqueous extracts of S.
hortensis and by the partially purified rosmarinic acid fraction.
The application of an aqueous S.
hortensis extract doubled the activity of catalase and superoxide dismutase in the cells.
The production of IL-2 and IL-10 interleukins was stimulated by H2O2 and was further enhanced by the addition of the S.
hortensis extract or rosmarinic acid fraction.
The H2O2-challenged Jurkat cells may serve as a model for investigating cellular mechanisms of cytoprotective phytonutrient effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chkhikvishvili, Irakli& Sanikidze, Tamar& Gogia, Nunu& Mchedlishvili, Tamar& Enukidze, Maia& Machavariani, Marine…[et al.]. 2013. Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472932
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chkhikvishvili, Irakli…[et al.]. Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-472932
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chkhikvishvili, Irakli& Sanikidze, Tamar& Gogia, Nunu& Mchedlishvili, Tamar& Enukidze, Maia& Machavariani, Marine…[et al.]. Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472932
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472932
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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