![](/images/graphics-bg.png)
Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress
Joint Authors
Mchedlishvili, Tamar
Rodov, Victor
Gogia, Nunu
Sanikidze, Tamar
Enukidze, Maia
Machavariani, Marine
Vinokur, Yakov
Chkhikvishvili, Irakli
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Summer savory (Satureja hortensis L., Lamiaceae) is used in several regions of the world as a spice and folk medicine.
Anti-inflammatory and cytoprotective effects of S.
hortensis and of its rosmarinic acid-rich phenolic fraction have been demonstrated in animal trials.
However, previous studies of rosmarinic acid in cell models have yielded controversial results.
In this study, we investigated the effects of summer savory extracts on H2O2-challenged human lymphoblastoid Jurkat T cells.
LC-MS analysis confirmed the presence of rosmarinic acid and flavonoids such as hesperidin and naringin in the phenolic fraction.
Adding 25 or 50 µM of H2O2 to the cell culture caused oxidative stress, manifested as generation of superoxide and peroxyl radicals, reduced cell viability, G0/G1 arrest, and enhanced apoptosis.
This stress was significantly alleviated by the ethanolic and aqueous extracts of S.
hortensis and by the partially purified rosmarinic acid fraction.
The application of an aqueous S.
hortensis extract doubled the activity of catalase and superoxide dismutase in the cells.
The production of IL-2 and IL-10 interleukins was stimulated by H2O2 and was further enhanced by the addition of the S.
hortensis extract or rosmarinic acid fraction.
The H2O2-challenged Jurkat cells may serve as a model for investigating cellular mechanisms of cytoprotective phytonutrient effects.
American Psychological Association (APA)
Chkhikvishvili, Irakli& Sanikidze, Tamar& Gogia, Nunu& Mchedlishvili, Tamar& Enukidze, Maia& Machavariani, Marine…[et al.]. 2013. Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472932
Modern Language Association (MLA)
Chkhikvishvili, Irakli…[et al.]. Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-472932
American Medical Association (AMA)
Chkhikvishvili, Irakli& Sanikidze, Tamar& Gogia, Nunu& Mchedlishvili, Tamar& Enukidze, Maia& Machavariani, Marine…[et al.]. Rosmarinic Acid-Rich Extracts of Summer Savory (Satureja hortensis L.) Protect Jurkat T Cells against Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-472932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472932