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Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats
المؤلفون المشاركون
Asmawi, Mohd Zaini
Ismail, Zhari
Dewa, Aidiahmad
Razali, Nadiah
Hassan, Zurina
Manshor, Nurul Maizan
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Orthosiphon stamineus Benth has been traditionally used to treat hypertension.
The study aimed to investigate the vascular reactivity of water extract (WOS) and water : methanolic (1 : 1) extract (WMOS) of Orthosiphon stamineus Benth and AT1 receptors blocker in the mechanisms of antihypertensive mediated by α1-adrenergic receptor and EDNO and PGI2 releases in the SHR aortic rings.
SHR (230–280 g) were divided into four groups: control, WOS, WMOS, and losartan.
After being fed orally for 14 days, the aorta was harvested and subjected to PE (10−9 to 10−5 M) and ACh (10−9 to 10−5 M) with and without L-NAME (100 µM) and indomethacin (10 µM), respectively.
WOS, WMOS, and losartan significantly reduced the contractile responses to PE intact suggesting the importance of endothelium in vasorelaxation.
Losartan significantly enhanced the ACh-induced vasorelaxation.
L-NAME significantly inhibited the ACh-induced relaxation in all groups.
Indomethacin enhanced ACh-induced vasorelaxation in WMOS.
Collectively, Orthosiphon stamineus leaves extract reduced vasoconstriction responses by the alteration of α1-adrenergic and AT1 receptors activities.
The involvement of EDNO releases was clearly observed in this plant.
In WOS, PGI2 releases might not participate in the ACh-induced vasorelaxation.
However, in WMOS, enhancement of vasorelaxation possibly due to continuous release of PGI2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Manshor, Nurul Maizan& Dewa, Aidiahmad& Asmawi, Mohd Zaini& Ismail, Zhari& Razali, Nadiah& Hassan, Zurina. 2013. Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472980
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Manshor, Nurul Maizan…[et al.]. Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats. International Journal of Vascular Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472980
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Manshor, Nurul Maizan& Dewa, Aidiahmad& Asmawi, Mohd Zaini& Ismail, Zhari& Razali, Nadiah& Hassan, Zurina. Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472980
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472980
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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