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Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats
Joint Authors
Asmawi, Mohd Zaini
Ismail, Zhari
Dewa, Aidiahmad
Razali, Nadiah
Hassan, Zurina
Manshor, Nurul Maizan
Source
International Journal of Vascular Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Orthosiphon stamineus Benth has been traditionally used to treat hypertension.
The study aimed to investigate the vascular reactivity of water extract (WOS) and water : methanolic (1 : 1) extract (WMOS) of Orthosiphon stamineus Benth and AT1 receptors blocker in the mechanisms of antihypertensive mediated by α1-adrenergic receptor and EDNO and PGI2 releases in the SHR aortic rings.
SHR (230–280 g) were divided into four groups: control, WOS, WMOS, and losartan.
After being fed orally for 14 days, the aorta was harvested and subjected to PE (10−9 to 10−5 M) and ACh (10−9 to 10−5 M) with and without L-NAME (100 µM) and indomethacin (10 µM), respectively.
WOS, WMOS, and losartan significantly reduced the contractile responses to PE intact suggesting the importance of endothelium in vasorelaxation.
Losartan significantly enhanced the ACh-induced vasorelaxation.
L-NAME significantly inhibited the ACh-induced relaxation in all groups.
Indomethacin enhanced ACh-induced vasorelaxation in WMOS.
Collectively, Orthosiphon stamineus leaves extract reduced vasoconstriction responses by the alteration of α1-adrenergic and AT1 receptors activities.
The involvement of EDNO releases was clearly observed in this plant.
In WOS, PGI2 releases might not participate in the ACh-induced vasorelaxation.
However, in WMOS, enhancement of vasorelaxation possibly due to continuous release of PGI2.
American Psychological Association (APA)
Manshor, Nurul Maizan& Dewa, Aidiahmad& Asmawi, Mohd Zaini& Ismail, Zhari& Razali, Nadiah& Hassan, Zurina. 2013. Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472980
Modern Language Association (MLA)
Manshor, Nurul Maizan…[et al.]. Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats. International Journal of Vascular Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-472980
American Medical Association (AMA)
Manshor, Nurul Maizan& Dewa, Aidiahmad& Asmawi, Mohd Zaini& Ismail, Zhari& Razali, Nadiah& Hassan, Zurina. Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-472980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-472980