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Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats
المؤلفون المشاركون
Molteni, Agostino
Herndon, Betty
Mehrer, Aaron
Kamal, Afrin
Nitz, Jonathan
Lawrenz, Joshua
Dim, Daniel C.
Baybutt, Richard C.
Gasper, David
Baidoo, Cletus
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Bleomycin, a widely used antineoplastic agent, has been associated with severe pulmonary toxicity, primarily fibrosis.
Previous work has shown a reduction in bleomycin-induced lung pathology by long-chain omega-3 fatty acids.
Treatment by short-chain omega-3 fatty acids, α-linolenic acid, found in dietary flaxseed oil may also reduce lung fibrosis, as previously evidenced in the kidney.
To test this hypothesis, 72 rats were divided between diets receiving either 15% (w/w) flaxseed oil or 15% (w/w) corn oil (control).
These groups were further divided to receive either bleomycin or vehicle (saline) via an oropharyngeal delivery, rather than the traditional intratracheal instillation.
Lungs were harvested at 2, 7, and 21 days after bleomycin or saline treatment.
Animals receiving flaxseed oil showed a delay in edema formation (P=0.025) and a decrease in inflammatory cell infiltrate and vasculitis (P=0.04 and 0.007, resp.).
At days 7 and 21, bleomycin produced a reduction in pulmonary arterial lumen patency (P=0.01), but not in rats that were treated with flaxseed oil.
Bleomycin-treated rats receiving flaxseed oil had reduced pulmonary septal thickness (P=0.01), signifying decreased fibrosis.
Dietary flaxseed oil may prove beneficial against the side effects of this highly effective chemotherapeutic agent and its known toxic effects on the lung.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lawrenz, Joshua& Herndon, Betty& Kamal, Afrin& Mehrer, Aaron& Dim, Daniel C.& Baidoo, Cletus…[et al.]. 2012. Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-472997
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lawrenz, Joshua…[et al.]. Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulmonary Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-472997
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lawrenz, Joshua& Herndon, Betty& Kamal, Afrin& Mehrer, Aaron& Dim, Daniel C.& Baidoo, Cletus…[et al.]. Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-472997
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-472997
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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