Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats

Joint Authors

Molteni, Agostino
Herndon, Betty
Mehrer, Aaron
Kamal, Afrin
Nitz, Jonathan
Lawrenz, Joshua
Dim, Daniel C.
Baybutt, Richard C.
Gasper, David
Baidoo, Cletus

Source

Pulmonary Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-08-08

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases
Medicine

Abstract EN

Bleomycin, a widely used antineoplastic agent, has been associated with severe pulmonary toxicity, primarily fibrosis.

Previous work has shown a reduction in bleomycin-induced lung pathology by long-chain omega-3 fatty acids.

Treatment by short-chain omega-3 fatty acids, α-linolenic acid, found in dietary flaxseed oil may also reduce lung fibrosis, as previously evidenced in the kidney.

To test this hypothesis, 72 rats were divided between diets receiving either 15% (w/w) flaxseed oil or 15% (w/w) corn oil (control).

These groups were further divided to receive either bleomycin or vehicle (saline) via an oropharyngeal delivery, rather than the traditional intratracheal instillation.

Lungs were harvested at 2, 7, and 21 days after bleomycin or saline treatment.

Animals receiving flaxseed oil showed a delay in edema formation (P=0.025) and a decrease in inflammatory cell infiltrate and vasculitis (P=0.04 and 0.007, resp.).

At days 7 and 21, bleomycin produced a reduction in pulmonary arterial lumen patency (P=0.01), but not in rats that were treated with flaxseed oil.

Bleomycin-treated rats receiving flaxseed oil had reduced pulmonary septal thickness (P=0.01), signifying decreased fibrosis.

Dietary flaxseed oil may prove beneficial against the side effects of this highly effective chemotherapeutic agent and its known toxic effects on the lung.

American Psychological Association (APA)

Lawrenz, Joshua& Herndon, Betty& Kamal, Afrin& Mehrer, Aaron& Dim, Daniel C.& Baidoo, Cletus…[et al.]. 2012. Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-472997

Modern Language Association (MLA)

Lawrenz, Joshua…[et al.]. Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulmonary Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-472997

American Medical Association (AMA)

Lawrenz, Joshua& Herndon, Betty& Kamal, Afrin& Mehrer, Aaron& Dim, Daniel C.& Baidoo, Cletus…[et al.]. Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-472997

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-472997