Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts
المؤلفون المشاركون
Oliver, Brian G.
King, Nicholas J.C.
Van Ly, David
Burgess, Janette K.
Moir, Lyn M.
Black, Judith L.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Rhinovirus-(RV-) induced asthma exacerbations account for high asthma-related health costs and morbidity in Australia.
The cellular mechanism underlying this pathology is likely the result of RV-induced nuclear-factor-kappa-B-(NF-κB-) dependent inflammation.
NF-κB may also be important in RV replication as inhibition of NF-κB inhibits replication of other viruses such as human immunodeficiency virus and cytomegalovirus.
To establish the role of NF-κB inhibitors in RV-induced IL- 6 and IL-8 and RV replication, we used pharmacological inhibitors of NF-κB, and steroids and/or β2 agonists were used for comparison.
Primary human lung fibroblasts were infected with RV-16 in the presence of NF-κB inhibitors: BAY-117085 and dimethyl fumarate; β2 agonist: salmeterol; and/or corticosteroids: dexamethasone; fluticasone.
RV-induced IL-6 and IL-8 and RV replication were assessed using ELISAs and virus titration assays.
RV replicated and increased IL-6 and IL-8 release.
Salmeterol increased, while dexamethasone and fluticasone decreased RV-induced IL-6 and IL-8 (P<0.05).
The NF-κB inhibitor BAY-117085 inhibited only RV-induced IL-6 (P<0.05) and dimethyl fumarate did not alter RV-induced IL-6 and IL-8.
Dimethylfumarate increased RV replication whilst other drugs did not alter RV replication.
These data suggest that inhibition of NF-κB alone is unlikely to be an effective treatment compared to current asthma therapeutics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Van Ly, David& King, Nicholas J.C.& Moir, Lyn M.& Burgess, Janette K.& Black, Judith L.& Oliver, Brian G.. 2011. Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts. Journal of Allergy،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-473018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Van Ly, David…[et al.]. Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts. Journal of Allergy No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-473018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Van Ly, David& King, Nicholas J.C.& Moir, Lyn M.& Burgess, Janette K.& Black, Judith L.& Oliver, Brian G.. Effects of β2 Agonists, Corticosteroids, and Novel Therapies on Rhinovirus-Induced Cytokine Release and Rhinovirus Replication in Primary Airway Fibroblasts. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-473018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر