Cumulative Effect of Depression on Dementia Risk
المؤلفون المشاركون
Trincado, R.
Olazarán, J.
Bermejo-Pareja, F.
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To analyze a potential cumulative effect of life-time depression on dementia and Alzheimer’s disease (AD), with control of vascular factors (VFs).
Methods.
This study was a subanalysis of the Neurological Disorders in Central Spain (NEDICES) study.
Past and present depression, VFs, dementia status, and dementia due to AD were documented at study inception.
Dementia status was also documented after three years.
Four groups were created according to baseline data: never depression (nD), past depression (pD), present depression (prD), and present and past depression (prpD).
Logistic regression was used.
Results.
Data of 1,807 subjects were investigated at baseline (mean age 74.3, 59.3% women), and 1,376 (81.6%) subjects were evaluated after three years.
The prevalence of dementia at baseline was 6.7%, and dementia incidence was 6.3%.
An effect of depression was observed on dementia prevalence (OR [CI 95%] 1.84 [1.01–3.35] for prD and 2.73 [1.08–6.87] for prpD), and on dementia due to AD (OR 1.98 [0.98–3.99] for prD and OR 3.98 [1.48–10.71] for prpD) (fully adjusted models, nD as reference).
Depression did not influence dementia incidence.
Conclusions.
Present depression and, particularly, present and past depression are associated with dementia at old age.
Multiple mechanisms, including toxic effect of depression on hippocampal neurons, plausibly explain these associations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olazarán, J.& Trincado, R.& Bermejo-Pareja, F.. 2013. Cumulative Effect of Depression on Dementia Risk. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-473020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olazarán, J.…[et al.]. Cumulative Effect of Depression on Dementia Risk. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-473020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olazarán, J.& Trincado, R.& Bermejo-Pareja, F.. Cumulative Effect of Depression on Dementia Risk. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-473020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر