Cumulative Effect of Depression on Dementia Risk
Joint Authors
Trincado, R.
Olazarán, J.
Bermejo-Pareja, F.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To analyze a potential cumulative effect of life-time depression on dementia and Alzheimer’s disease (AD), with control of vascular factors (VFs).
Methods.
This study was a subanalysis of the Neurological Disorders in Central Spain (NEDICES) study.
Past and present depression, VFs, dementia status, and dementia due to AD were documented at study inception.
Dementia status was also documented after three years.
Four groups were created according to baseline data: never depression (nD), past depression (pD), present depression (prD), and present and past depression (prpD).
Logistic regression was used.
Results.
Data of 1,807 subjects were investigated at baseline (mean age 74.3, 59.3% women), and 1,376 (81.6%) subjects were evaluated after three years.
The prevalence of dementia at baseline was 6.7%, and dementia incidence was 6.3%.
An effect of depression was observed on dementia prevalence (OR [CI 95%] 1.84 [1.01–3.35] for prD and 2.73 [1.08–6.87] for prpD), and on dementia due to AD (OR 1.98 [0.98–3.99] for prD and OR 3.98 [1.48–10.71] for prpD) (fully adjusted models, nD as reference).
Depression did not influence dementia incidence.
Conclusions.
Present depression and, particularly, present and past depression are associated with dementia at old age.
Multiple mechanisms, including toxic effect of depression on hippocampal neurons, plausibly explain these associations.
American Psychological Association (APA)
Olazarán, J.& Trincado, R.& Bermejo-Pareja, F.. 2013. Cumulative Effect of Depression on Dementia Risk. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-473020
Modern Language Association (MLA)
Olazarán, J.…[et al.]. Cumulative Effect of Depression on Dementia Risk. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-473020
American Medical Association (AMA)
Olazarán, J.& Trincado, R.& Bermejo-Pareja, F.. Cumulative Effect of Depression on Dementia Risk. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-473020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-473020