Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis
المؤلفون المشاركون
Kamiya, Takeshi
Tanida, Satoshi
Joh, Takashi
Mizushima, Takashi
Shimura, Takaya
Mizoshita, Tsutomu
Kataoka, Hiromi
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In ulcerative colitis (UC), the duration and severity of inflammation are responsible for the development of colorectal cancer.
Reactive oxygen species (ROS), reactive nitric metabolites (RNMs) and interleukin (IL)-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer.
Nitric oxide and peroxynitrite activate epidermal growth factor receptor (EGFR), and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer.
IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM).
The cleaved HB-EGF and C-terminal fragments (intracellular CTF) regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively.
Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tanida, Satoshi& Mizoshita, Tsutomu& Mizushima, Takashi& Shimura, Takaya& Kamiya, Takeshi& Kataoka, Hiromi…[et al.]. 2010. Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis. Ulcers،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473062
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tanida, Satoshi…[et al.]. Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis. Ulcers No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473062
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tanida, Satoshi& Mizoshita, Tsutomu& Mizushima, Takashi& Shimura, Takaya& Kamiya, Takeshi& Kataoka, Hiromi…[et al.]. Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis. Ulcers. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473062
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-473062
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر