Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis

Joint Authors

Kamiya, Takeshi
Tanida, Satoshi
Joh, Takashi
Mizushima, Takashi
Shimura, Takaya
Mizoshita, Tsutomu
Kataoka, Hiromi

Source

Ulcers

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-10-26

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases

Abstract EN

In ulcerative colitis (UC), the duration and severity of inflammation are responsible for the development of colorectal cancer.

Reactive oxygen species (ROS), reactive nitric metabolites (RNMs) and interleukin (IL)-8, released by epithelial and immune cells, are involved in the pathogenesis of colitis-associated cancer.

Nitric oxide and peroxynitrite activate epidermal growth factor receptor (EGFR), and therapeutic agents targeted towards EGFR are currently used to treat advanced colorectal cancer.

IL-8 (a G-protein coupled receptor (GPCR) agonist), which is involved in neutrophil recruitment and activation in persistent active colitis, also promotes cleavage of the proheparin-binding epidermal growth factor-like growth factor (proHB-EGF) through a disintegrin and metalloproteinase (ADAM).

The cleaved HB-EGF and C-terminal fragments (intracellular CTF) regulate proliferation via EGFR activation and nuclear export of promyelocytic leukemia zinc finger, transcription repressor, respectively.

Here, we focus on the mechanisms by which RNM- and IL-8-induced EGF signaling regulate cell proliferation during the development of colitis-associated cancer.

American Psychological Association (APA)

Tanida, Satoshi& Mizoshita, Tsutomu& Mizushima, Takashi& Shimura, Takaya& Kamiya, Takeshi& Kataoka, Hiromi…[et al.]. 2010. Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis. Ulcers،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473062

Modern Language Association (MLA)

Tanida, Satoshi…[et al.]. Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis. Ulcers No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-473062

American Medical Association (AMA)

Tanida, Satoshi& Mizoshita, Tsutomu& Mizushima, Takashi& Shimura, Takaya& Kamiya, Takeshi& Kataoka, Hiromi…[et al.]. Involvement of Cell Proliferation Induced by Dual Intracellular Signaling of HB-EGF in the Development of Colitis-Associated Cancer during Ulcerative Colitis. Ulcers. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-473062

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-473062